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- Debating AZT,
Mbeki and the AIDS drug controversy
-
- Zurich 1st May 2001
-
- Dear Sir or Madam
- As it was demonstrated by various
studies, that we have sent you since 1990
the common agent in the many varied diseases that can define the AIDS
syndrome is an hightened level of nitric oxide and oxigen radicals
and an ongoing deficiency in
glutathione molecules, that induces the suppression
of cellular im-mune reactions (dedection and destruction of cells
contining viruses, fungy and myccobacteria) and a higher activity of
reverse transcription and a higher release of antibodies and
cellular protein fragments (delcared
to be HIV-virusparticles).
- A hightened level of oxigen radicals
and nitric oxide is caused by repeated
infections (due to repeated injury and dirty water), by contact to
toxines (from the environment and from drugs) and by the repeated contact
of foreign proteins to the plasma (by semen in unsafe anal intercourse
or by coagulation proteins administrated in high quantities to
hemophiliacs. The deficiency of glutathione molecules (which can
be mesured in any person making
a positive result in HIV-antibody tests), goes
back to malnutrition (which can lead to a deficient formation of the
thymus gland in the childhood), to chronic hepatitis and to
- over-exertation of the glutathion
system by drugs with a high oxidative potential
(e.g. chemo-antibiotics).
- In regard of this well-documented
interactions, the administration of s.c.
nucleosid analog drugs like AZT (Retrovir) does not have any therapeutic
effect on the principal mechanism in AIDS defining illnesses.
As it was demonstrated by studies and animal tryals since 1990
this cytotoxic drugs are only to 1% incoor-perated into the cellnucleus,
where they should inhibit the postulated HIV-retroviruses.
- They have a cyto-static effect,
destroying any kind of sane and weakened cells
(and therby also fungy and myccobacteria) and effect severe damage
to the mitochondrial DNA and
therby severe damage to the bone marrow, the
brain, the muscles and internal organs (that have been declared by
the producer of AZT, Glaxo, to
be the effects of to the HIV-retroviruses and
of individual reactions of carriers of this virus).
- After the presidential AIDS panel,
where the causes and the appropriate preventive
and therapeutic mesures against AIDS defining illnesses have been
discussed, the South African attorney Mr. Anthony Brink has
wirtten a report on the AZT
controversy in South Africa (available at www.virusmyth.com
front-news: "Open letter to Glaxo") in which he shows all
the important data on this drug. Mr. Brink launches out an action
in
- South Africa against Glaxo to verify
clearly the effects and the side effects
of AZT (Re-trovir), which should be widespreadly administrated in
South Africa according to the the uncessant claim of international
organisations, that is promoted
by important pharmaceutical companies and
mass media.
- If you need further information on
the facts mentioned above, don't hesitate
to get back on us.
- Yours faithfully
-
- Felix A. de Fries
Study group for AIDS therapy- Enclosure: -Treatment
recommendations new version including the role of foreign
proteins AIDS defining
illnesses, their causes and treatment
- (Treatment recommendations based on
the works of Dr. Heinrich Kremer, Hamburg,
Prof. Alfred Häs-sig, Berne), Dr. Stefan Lanka (Suttgart) and Eleni
Papadopulos-Eleopulos (Royal Hospital, Perth) available at www.virusmyth.com
and works of L. A. Herzenberg, J.D. Peterson and S.C. De
Rosa (Stanford University)and of Furchgott and Ignarro avaiable at
- www.ncbi.nlm.nih.gov
- The many and varied diseases that
can define the AIDS syndrome: fungal infections
of the lung, of the mucous membranes, the brain, and the gut, and
the degenerative chan-ges in the endothelial cells of blood
vessels and lymphatic vessels (Kaposi
Sarcoma), occur because of an ongoing heightened
production of gaseous nitricoxide and oxygen radicals in immune
cells and other cells. Under these conditions CD4 helper cells ma-ture
predominantly to cells with TH2 cytokine prophile, which migrate to
the bone mar-row, where they activate defences against bacteria by
producing antibodies, but only
few mature to TH1 cells mesurable in plasma,
which activate the dedection and destruc-tion of fungus and virus
infected cells and of altered cells. If this situation per-sists, a
higher quantity of proteins of the cytoskeleton and of
mitochondria is relea-sed as en
effect of heightened cell decay. Against these proteins a
higher rate of the antibodies are formed. This antibodies and antibodies
that occure in hepatitis and due to toxic pollution are detected
by the HIV-antibody tests. Once a certain, arbitrary level is reached,
the patient is declared "HIV positive".
- A persistently elevated level of
nitricoxide and oxygen radicals comes
- about as a re-sult of:
- - ongoing contact with antigens
(e.g. from repeated or chronic
- infections, injuries, operations and
dirty water).
- - repeated contact of foreign
proteins to the plasma (from coagulation proteins
for hemophilliacs and from semen in unsafe anal intercourse)
- - contact to toxic substances in
food, medicaments and from environment pollution,
toxic decomposition products from modern chemicals (heavy metals
(carrier substan-ces in vaccines, amalgan fillings), adjuvants in nutritiens,
colors etc.),
- - inhalation of nitrites
("poppers") which are stored in cells as NO2. They
are re-leased through physical exertion on increased exposure to calcium
ions. This af-fects the endothelial cells of blood vessels and lymphatic
vessels with a small capillary diameter, and leads thereby to degenerative
changes (swollen lymph nodes and finally to Kaposi Sarcoma).
- - impairment of the mitochondria,
the single cell energy suppliers, which
synthesize the energy-carrying-molecule ATP, used for all functions
of the organism
- The causes of chronic mitochondrial
damage are:
- - damage of the mitochondrial DNA
due to antibiotics (e.g. sulpha compounds
such as Septrime, TMPSMX) which block the synthetisation of folic
acid and purine, and lead thereby to the exhaustion of the mitochondrial
thiol-pool. Likely effects are caused by heavy metals and by
cytostatics like AZT. All this substances bind the SH-groups of glutathione
and cysteine and impair thereby the activity of mitochon-dria.
- - reduced glutathione produced
resulting from liver damage, e.g. chronic hepatitis
(occuring frequently in gay men, hemophiliacs and intravenuous drug
consumers), excessive alcohol consumption, or through shortage of nutritional
cysteine, esp. in developing countries. Glutathion molecules reduce
oxygen- and nitricoxydemole-cules, so that ATP production in mitochondria
is not disturbed. An ongoing shorta-ge of glutathione means that
phagozyte poison themselves attacking fungi and virus containing cells
by means of NO.
- - reduced oxygen transport in cells
because of oxidation
- (methhaemoglobinaemia) which exceeds
the reductive capacity of glutathione.
This comes about because of the strongly oxidising effect of
nitrites (poppers), antibiotics (Septrime, TMPSMX) and
insecticides (e.g. Lindan in
ointment against crab louse), nucleoside analogues, heavy
metals and chemicals.
- - lack of plant antioxidants which
bind to toxic degradation products (oxygen
radi-cals) and thereby reduce inflammation and stressreactions. On
prolonged impairment of mitochondria, they dissolve their
symbiosis with the host ("Warburg
Phenomenon"). Cells then increasingly switch over
to producing energy by anaerobic fermentation, which results in
- excess lactic acid production, and
the growth of fungi and opportunists, and
ultimately to wasting, at which point cells obtain es-sential nutrients
directly from the myoproteine. By an heightened activity of reverse
transcription the cellnucleus then saves its genotype.
- Continuous activation of
macro-phages leads in this situation to an ongoing
release of messanger substances (Inteleu-kine 2) which trigger the
release of stress-hormones in the adrenal gland. This hormo-nes induce
the formation of TH2 CD-4 cells, that activate the formation of antibodies
in the bone marrow, whereas cellular immune reactions induced by
TH1 cells are conti-nuously suppressed.
- By means of:
- - A supply of sulphur compounds in
sea salt, mineral water and algal products,
and of cysteine and methionine containing protein mixtures, (Cysteine,
N-acetyl-cysteine and arginin, (3-8 gramme daily)also in curd and
whey) and folic acid (300 miligramme daily) can stimulate glutathione
formation in the liver. Glutathione must be administered in the
mean time intravenously (600 milligramme daily) untill its
formation in the liver works
sufficiently again.
- - Plant antioxidants, e.g. PADMA 28
(2-3 times 2 tabletts daily) or artemisia
ouemba which bind to toxic oxygen decay products, and natural protease
inhibitors (hepa-rine and heparinoids in agar, algae or cartilage
preparations), which activate the body's own anti-proteases and
bind to cations that attack the cell walls, can slow down chronic inflammatory
reactions going allong with increased cell division.
- - Co-enzyme Q10 and NADH and high
doses of Vitamin C and E can improve electron
transport in the respiratory chain of cells. Folic acid (300 milligramme
daily), thiols L-carnitin and low doses of selenium, (e.g. brewers'yeast),
and zinc can support the synthetisation of ATP in mitochondria
and the repair of damage to mi-tochondrial DNA.
- - Opportunistic infections (fungy,
PCP and others can be treated by omega-3
fatty acids in fishoil (3 tablespoons daily) In dificult cases gamma
globulin, selective cyclooxygenese-2 inhibitors and difluoromethylornithine
as a polyamine inhibitor can be administrated.
- The activity of killer cells and
neutrophillia can be sup-ported by the administration
of glutamine (40 grammes daily) and L-Arginin (20-30 grammes
daily).
- - DHEAS (200 milligrammes daily) can
diminish ongoing stress reactions in
the immune system (TH1-TH2-switch) caused by the release of stresshormones
(cortisol) in the adrenal gland.
- - Essential fatty acids in linseed
oil, thistle oil, soya oil and
- omega-3 fatty acid in fish oil mixed
with curd, which enhighten the uptake
of oxygen in cells
- - Carduus marianus to support the
liver and partly fermented beverages that
can restore the gut flora
- - Ethereal oils, rubbed on to the
chest and in the armpits serve to
- stimulate the immune system through
the ground substance (matrix)
- - Extract of grape fruit kernels (Citricidal)
and gargling with
- honey/vinegar are helpful as a local
treatment against fungal infection.
- - Targeted stress reduction
techniques, e.g. autogenic training,
- stretching and mas-sages, and
refraining from excesive physical exercise (using
perfomance-enhancing drugs, e.g. coffee, alcohol, nicotine, amphetamines
(X-tasy), cocaine, heroin and poppers.)
- - avoiding inflammatory reactions
and infection by avoiding injuries (in anal
inter-course with condom).
- - of a nourishment poor in sugar amd
acid but rich in roughage and bases,
with much high-value carbohydrates and potatoe, plant antioxidants,
e.g. vegetables, fruit, herbal and green teas,
- cold-pressed oils, partly fermented
dairyproducts, algae, soya beans, and
fish but not iron-rich red meat.
- ....a flexible resistance in people
with AIDS defining illnesses can be restored.
- If limited administration of
antibiotics is necessary, this basic therapy
has to be continued. Progress achieved by these measures to bolster
the immune system can be mo-nitored by measuring stress hormone profiles,
the T4/T8 cell ratio, macrophage activa-tion (neopterine test) and
cutaneous anergy, the glutathione level in plasma and in T-4
helper cells.
- HIV, which is held to be responsible
for causing 30 different
- AIDS-defining diseases, has never
been shown to be transmissible nor self-reproducing;
it has never been iso-lated, photographed or otherwise properly
characterised, as required by the esta-blished rules of virology.
The original experimental technique of Gallo and Montagnier in 1984
on which the HIV-antibody-tests were constructed, involved culturing
cells from AIDS patients with leucaemic cells and embryonal cells,
that show a high activity of reverse transcription. This effect
- of an artificially amplified reverse
transcrip-tion was then interpreted as
signifying the presence a new virus. A virus-specific en-zyme
could not be aprooved according
to the established rules. Synthetic protease in-hibitors,
which are supposed to inhibit the formation of essential viral
building blocks, over time, cause malaise, diabetes, kidney stones
- and liver failure in pati-ents given
them. After PIs and nucleoside
- analogues are first given, an
apparent de-cline in inflammatroy
- reactions and „virus
production" may be observed, but it then rises again,
which is attributed to resistance developping. Nucleoside analog drugs,
that destroy for a limited time through cytostatic effects bacteries
and fungy, are only ever 1% incorporated into the cell nucleus,
where they should work as DNA termi-nators against HIV. As it has
been demonstrated by animal trials since 1990 they cause irreversible
damage to the mitochondrial DNA and thereby damage to the brain,
the bone marrow, the muscles and internal organs.
- Study Group for AIDS therapy c/o
- Felix A. de Fries
- Eglistr. 7 CH-8004 Zürich Tel./FAX:
0041 1 401 34 24
- e-mail: felix.defries@bluewin.ch
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