The multiple
and various AIDS-defining illnesses, including fungal infections of the
lung, mucosa, brain, and gut, as well as Kaposi’s sarcoma, occur due to
the dynamic alteration of the formation of gaseous nitric oxide and
oxygen radicals in cells of the immune and other systems. These changes
can be provoked by innumerable causes, either chronic or acute,
especially in those so predisposed by their genetics or exposure to
toxins. The pathophysiology of AIDS is intimately connected with the
master antioxidant glutathione. A lack of glutathione in
antigen-presenting cells causes inhibition of the cell-mediated
immunity. Glutathione is also involved in regulation of the complex
symbiosis between the mitochondria and the archaic nuclear genome.
In the early
stages of glutathione deficiency following severe and/or chronic
oxidative stress, CD4 helper cells predominantly mature under the Th2
cytokine profile. These antibody-helper cells migrate from the
bloodstream to the lymph, where they stimulate B cells to produce
immunoglobulins against pathogenic molecules (i.e. bacteria and toxins).
Conversely, only a few CD4 cells mature into the Th1 cells needed to
carry out the detection and destruction of abnormal cells (both
defective cells, as well as those infested with fungus, virus,
mycoplasma, etc.). If this imbalanced situation persists, the release of
gaseous nitric oxide (NO) becomes entirely inhibited, to the point that
the cytotoxic immune defense against viruses, fungi and mycobacteria is
entirely blocked.
As a result
of heightened cellular decay, large quantities of cytoskeletal and
mitochondrial proteins are released into the extracellular matrix.
Subsequently, a higher than normal titre of antibodies are formed
against these normally hidden proteins. These polyspecific antibodies,
formed against both endogenous intracellular debris and a wide variety
of antigens and toxic byproducts, are what are detected by the so-called
“HIV tests.” Once an arbitrarily chosen threshold has been reached, the
patient is declared “HIV positive.” In this manner, testing “HIV+” is a
cardinal indicator of early glutathione deficiency.
In reality,
the “HIV characteristics” (virus-like cellular waste particles and
reverse transcription) are merely indicators of an
evolutionarily-programmed counterregulation provoked by repeated
oxidative stress, and not causal mechanisms in and of themselves.
After
prolonged impairment due to oxidative and nitrosative stress (i.e.
intracellular glutathione deficiency), the mitochondria dissolve their
symbiosis with the host ("Warburg Phenomenon”) and the nuclear DNA
maintains survival via reverse transcription of the protistan subgenome,
the archaic remnant of cellular endosymbiosis. Characteristic to this
cellular dysbiosis, the cells switch over to energy production via
anaerobic fermentation in the cytoplasm, resulting in excess lactic acid
and ultimately the formation of cancer and subsequent wasting (i.e.
cachexia, at which point cells obtain essential nutrients directly from
muscle protein).
The following factors influence the switching of
T4-helper cells from the Th1 to Th2 cytokine profile:
- A genetic
or non-genetic disposition for strong redox ability, especially
prevalent since 1945 with the widespread use of modern vaccines and
intracellular antibiotics (thus damaging the mitochondrial genome passed
on by the mother). When one so predisposed encounters the toxic
stressors that are now normal to contemporary life (i.e. environment,
diet, and medication), a quicker and more lasting Th1-to-Th2 switch
occurs (Type-II counterregulation against oxidative overstimulation,
inhibiting the biosynthesis of glutathione and other antioxidant
enzymes).
- Frequent
contact with antigens from repeated injuries or surgical operations,
chronic infections, unclean drinking water, repeated contact of foreign
proteins to the plasma (from clotting proteins in blood products and
from seminal fluid in unprotected anal intercourse); repeated contact
with toxic substances in food (e.g. aflatoxin in peanuts and cereal
grains, benzopyrenes in barbecued foods), medical and recreational
drugs, and environmental pollution (car exhaust, cigarettes, etc.);
toxic decomposition products from modern chemicals (e.g. solvents,
fungicides, insecticides, textile dyes, formaldehyde); and heavy metals
such as mercury and aluminum in vaccine carrier substances and dental
amalgam fillings. Frequent contact with antigens, toxins and toxic decay
products cause an ongoing activation of the cell-mediated defense with
an excessive release of gaseous nitric oxide (NO). This eventually leads
to a reduction in the release of Th1-type cytokines, a heightened
expenditure of sulfurous antioxidants (thiols), and a continuous change
in the redox potential of cells—the end result is an ongoing
counterregulation toward the Th2-type cytokines, those which activate
the B-cells to commence production of antibodies against external
antigens (bacteria and toxins).
- The
ingestion of nitrites from contaminated water, preserved foods, and
especially by inhalation of "poppers". Nitrites metabolize into excess
NO, which inhibits the synthesis of Th1-type cytokines and the ripening
of T4 (a.k.a. CD4+); thereby they a persistent Th1-to-Th2 switch, which
ultimately leads to cancer cell transformation (carcinogenesis by
fetalization). Nitrites are stored in cells as NO2 and later
released through physical exertion on increased exposure to calcium
ions. This disturbs the endothelial cells that line the blood vessels
and lymphatic capillaries, thereby leading to degenerative changes in
the skin, lymph nodes and other organs (Kaposi’s sarcoma).
- Continuous
intake of antibiotics (i.e. Trimethoprim and sulphonamides e.g.
cotrimoxazole, a.k.a. Bactrim/Septra/Septrim and TMP/SMX) and nucleoside
analog drugs (i.e. AZT, ddI, ddC, 3TC, etc.). These drugs inhibit the
synthesis of folic acid and purines, used in cells for the formation of
the mitochondrial DNA. They also inhibit iron- and copper-containing
enzymes, bind the SH-groups of glutathione and cysteine, and close the
mitochondrial membrane, thereby impairing mitochondrial activity.
Mitochondria are the power plant of all human cells; with reduced oxygen
and electrons from energy-rich nutritional components, they synthesize
ATP, the energy-carrying and life-sustaining molecule that is necessary
for every function in the organism. The mitochondria also reduce toxic
oxygen radicals, playing an important role in the immune system.
Chemoantibiotics also inhibit the synthesis of the enzyme
dihydrofolatereductase (DHFR), which is needed for the formation of
tetrahydrofolate, used in the liver for the synthesis of cysteine and
glutathione molecules, and for the synthesis of gaseous nitric oxide
(NO) used by neutrophils, killer cells and macrophages to attack and
destroy cells carrying fungi, viruses and mycobacteria.
-
Antibiotics, nucleoside analog drugs, insecticides (e.g. Lindane in
lotions against crablouse) and nitrites (poppers), by their strongly
oxidizing nature cause a deficiency in cellular oxygen transport
(methaemoglobinaemia) that exceeds the reductive capacity of glutathione
molecules.
- An
insufficiency of glutathione molecules can result from chemoantibiotic
therapy, liver damage (from hepatitis and frequent alcohol consumption)
or through shortage of nutritional cysteine (esp. in developing
countries). Glutathione molecules reduce oxygen- and nitric oxide
molecules, so that the ATP production in the mitochondria is not
disturbed. A lack of glutathione molecules allows fungi grow, which then
release toxic decay products (e.g. acetaldehyde) that can only be
decomposed by glutathione molecules and glucuronic acid. This further
weakens the biosynthesis of glutathione in the liver. A lack of
glutathione in antigen-presenting cells causes CD4+ helper cells to
mature predominantly as Th2 cells rather than Th1-type. Th2 cells
activate the formation of antibodies against external pathogens in the
bone marrow, while Th1 cells induce the detection and destruction of
cells containing viruses, mycobacteria and fungi by killer cells using
gaseous nitric oxide (NO).
- A dietary
lack of phyto-antioxidants from plants. These diverse substances bind to
toxic degradation products (oxygen radicals), and thereby reduce
inflammation and stress reactions.
The actual effects of "anti-retroviral" treatment:
Chemoantibiotics inhibit the synthesis of folic acid, purines, and the
enzyme dihydrofolatereductase (DHFR). They damage the mitochondrial DNA,
which is inherited from the mother to the child, and inhibit the
biosynthesis of glutathione molecules by the liver, used i.a. for the
reduction and transportation of oxygen to the cells. They also inhibit
the formation of gaseous nitric oxide (NO), necessary for the
destruction of cells containing viruses, fungi and mycobacteria; by
doing so they continuously block the entire cell-mediated branch of the
immune system. This causes a lasting Th1-to-Th2 switch in the cytokine
profile of CD4+ helper cells, effectively inducing an ongoing functional
immune deficiency. By long-term suffocation of the cellular respiration
they induce chronic fungal infestation (e.g. PCP, Candida albicans) in
mucous membranes, in the intestine (causing chronic diarrhea) and on the
skin. Due to the damage to mitochondrial DNA, they cause lasting energy
decline and severe damage to the brain, internal organs and muscles,
causing heart attacks and paralysis. They also inhibit the release of
tetrahydrofolate, which is used for the synthesis of uracil. Uracil
deficiency results in the inhibition of production of the growth factor
Interleukin-2. By inhibiting the production of the biologically active
form of folic acid, they also inhibit the transformation of the RNA-base
uracil into the DNA-base thymidine and thereby prevent the repair of DNA
by means of reverse transcription.
Nucleoside
analog drugs (a.k.a. NRTIs, e.g. Zidovudine/Retrovir, Nevirapine,
Abacavir, etc.), after a short time of administration inhibit the
ripening of immune cells in the mucous membrane (B-cells, T-cells,
macrophages and dendritic cells). The disruption of the maturation of
B-cells causes a decrease of their number and activity, and thereby the
weakening of the antibacterial defense by antibodies, inviting
persistent bacterial infections. If Th2-CD4+ cells then circulate, they
only meet a limited number of B-cells that they can activate. Without
contact to B-cells, most of the Th2 cells uselessly circulate for 24
hours through the bloodstream; due to their limited Th2 programming they
are unable to facilitate the detection and elimination of cells that
contain viruses, fungi and mycobacteria. Thus the rise in CD4 counts is
a secondary result of B-cell defects due to chemotoxic poisoning. The
naïve measurement of circulating T4 cells gives a misleading sense of a
rebounding immune system, because Th2 cells are not programmed to
synthesize cytoxic nitric oxide gas in the inflammatory immune defense
(Th1). Further tests such as cytokine profiling are necessary to
ascertain the Th1/Th2 balance.
Nucleoside
analog drugs, protease inhibitors and fusion inhibitors all disrupt the
biosynthesis of proteins, enzymes, and nucleic acids, all of which are
essential for the formation of new cells in all organs. In this manner
they also corrupt the genetic coding in the cell nucleus and the
mitochondria. This genetic damage initiates the DNA repair mechanism of
reverse transcription (RNA messages are converted into DNA “patch
kits”). When DNA has been damaged, the increased rate of RNA
production is measurable in the plasma; this is misinterpreted as the
"viral load". After a short period of HAART treatment, the massive
genetic chemo-damage initiates a heightened repair process, such that
consumption of RNA is increased; in this way the RNA plasma level drops
towards “undetectable.”
By their
glutathione-exhausting nature, these drugs selectively enhance cellular
dysbiosis and increase risk of cancer. Eventually, the suffocation of
the repair enzymes makes it impossible for the products of reverse
transcription (the so-called PCR “HIV RNA”) to be used for DNA repair,
such that their number increases again (misinterpreted as “HIV
resistance”). In reality, fluctuations of plasma RNA are due to the
battle between vicious chemotoxins and the healthy DNA repair process.
Nucleoside analog drugs provide a short-term pseudo-benefit as
antimicrobials; they block the formation of DNA in bacteria and fungi
until genuine “resistance” occurs. However they are only negligibly
incorporated into the cell nucleus, where they supposedly work as DNA
terminators against “HIV”. As has been demonstrated by various animal
trials since 1988, they cause irreversible damage to the mitochondrial
DNA, thereby damaging the brain, bone marrow, muscles and internal
organs, and also causing a lasting decline in CD4 and CD8 cells,
eventually promoting the opportunistic infections (cytomegalovirus,
herpes simplex, PCP and toxoplasmosis) which define the AID-Syndrome.
Synthetic
protease inhibitors, which are supposed to specifically target essential
components of "viral particles", actually inhibit normal human aspartyl
proteases such as pepsin. They also inhibit the synthesis of nucleotides
needed for the formation of new cells in all organs, and thereby cause
malaise, diabetes, kidney stones, osteoporosis, bone necrosis, and liver
failure in patients ingesting them on a long-term basis. They have been
shown to have antifungal and antimicrobial effects, as well as potential
mild-antioxidant nature due to their polyphenolic structure, which may
explain the temporary “Lazarus effect.”
While the
aforementioned glutathione-exhausting chemotoxic drugs are strongly
implicated, the ultimate causal mechanism of disease progression in AIDS
is the downward spiral of inflammatory oxidative stress and
cysteine/glutathione insufficiency, accelerated by cortisol, leading to
a bioenergetic nuclear-mitochondrial dysbiosis and a persistent
deficiency in Th1/NO immune defense.
The following are some powerful, non-toxic means to
restitute cell-symbiosis and a flexible capacity for immune defense:
• Curcumin
(Pro Curmin Complete (
www.tisso.de
) 4 capsules daily), extracted from the spice
plant Curcuma longa (turmeric) and supplemented with peperino,
quercetin, molybdenum, grape seed extract and the medicinal mushroom
Agaricus blazei murill inhibits in the ultraviolet range every signal
responsible for the progression of inflammations, opportunistic
infections and degenerative developments (cancer). It cannot be taken in
conjunction with high doses of vitamin C, E and beta carotene,
especially in cases of glutathione deficiency, as it changes into a
substance that has a prooxidative effect and it can no longer deploy its
anti-infectious effects (vitamin C itself, in the presence of transition
metals like iron (Fe) and copper (Cu) transforms into a prooxidative
substance and thus aggravates a glutathione or thiol deficiency).
-
With S-acetyl-L-glutathione (400-600mg daily) in tablets resistant to
gastric juice mixed with Gingko biloba and anthocyanins, the deficit of
intracellular glutathione can be corrected. If digestive trouble occurs,
SAG can be administered via oral spray. At the beginning of treatment to
restitute the balance, and also in acute situations, up to 5 grams of
glutathione can be administrated daily, intravenously or parenterally.
- A supply of
sulfur compounds (thiols), in protein mixtures containing cysteine and
methionine, can also stimulate glutathione formation in the liver
(cysteine / N-acetyl-cysteine (NAC) 3-8g daily). Cysteine can also be
administered intravenously until the liver can again sufficiently
synthesize glutathione.
• The
electron transport of the respiratory chain of mitochondria can be
improved with the co-enzyme Q10 (100 – 200 mg daily). The mitochondrial
activities and the repair of damage to mitochondrial DNA can be
supported by folic acid (5 – 20 mg daily), alpha lipoic acid (300 – 600
mg daily), through vitamin B1 (150 – 300 mg daily), B6 and B12 and doses
of selenium (250 micrograms), zinc (10 mg daily), magnesium, manganese
and the medicinal mushroom Lingzhi (contained in Pro Dialvit,
www.tisso.de
), as well as through chromium (100 – 300
micrograms daily) and uridine (the latter in molasses, 2 dessert spoons
daily).
-The activity
of killer cells and neutrophils (occurring in wasting) can be supported
by the administration of L-glutamine (40g daily) and L-arginine (20-30g
daily), and of beta-1,3-D-glucan (
www.altcancer.com
) and RM-10 (
www.hmdistributor.com
) derived from medicinal mushrooms such as Shiitake
and Maitake, containing a special mix of polysaccharides and amino
acids.
- L-carnitine
is necessary for the incorporation of long-chain fatty acids
(triglycerides) into the mitochondria. A deficiency of L-carnitine
impedes the energy-releasing process of glycolysis. By the
administration of 6 grams of L-carnitine daily for 14 days, this
deficiency can be resolved.
-
Opportunistic infections (fungi, PCP and others) can be treated by
omega-3 fatty acids in evening primerose oil or fish oil (3 tbs daily)
and microalgae (e.g. chlorella 3-4g daily), which activate cellular
immune reactions via prostaglandin modulation. In difficult cases,
gammaglobulins, selective cyclooxygenase-2 inhibitors, and
difluoromethylornithine (as a polyamine inhibitor) can be administered.
- Essential
fatty acids in fresh flaxseed, hempseed, thistle, or soybean oils (5-6
tbs daily) mixed with curd (cysteine), can heighten the uptake of oxygen
into cells.
- Polyanions
(heparin and heparinoids) in agar seaweed, guar shark cartilage or green
mussel preparations, work as natural protease inhibitors. They protect
the negatively charged matrix that plays an important role in the immune
system, activate the body's own antiproteases and bind to cations that
attack the cell membrane. Thereby they slow down chronic inflammatory
reactions occurring with increased cell division.
-Thiocyanates
in onions, broccoli, cabbage and garlic help activate liver
detoxification enzymes. Glucuronic acid (in the fermented tea beverage
kombucha, made from a symbiotic yeast/bacterial “mushroom”), and herbal
medications, (milk thistle, boldo, artishoke Liv 52) can support the
liver function in those with additional stress such as hepatitis.
- The balance
between cell-mediated and antibody-mediated immune reactions (Th1-Th2
switch) is hormonally controlled by the hypothalamic-pituitary-adrenal
(HPA) axis. The antibody-mediated defense is activated by cortisol, the
stress hormone produced by the adrenal glands. Its hormonal antagonist
is DHEA, which is stored throughout the body, activates the
cell-mediated defense. With the administration of DHEA-S, ongoing stress
reactions and the heightened production of Th2 cells can be mitigated.
The use of steroid hormones to enhance muscle formation is
contraindicated, as it disrupts the HPA axis resulting in continuous
immune suppression.
- Fungal
infestations of the intestines (e.g. Candida albicans) can be treated
quite effectively by coconut-derived caprylic acid in capsules resistant
to gastric acids (e.g. Mycopril from Biocare UK). Other effective
treatments include grapefruit seed extract, biotin (vitamin H, depleted
by raw egg whites), whole-leaf Aloe vera juice, Artemisia annua
(wormwood), astringent/tannic herbal extracts (goldenseal, barberry,
chamomile, echinacea, black walnut, etc.), Pau d’Arco tea, essential
oils of oregano and cinnamon, castor oil, and garlic. The foundation of
such treatment is a special diet, one must avoid all sugary and
refined foods, including sweet fruits, alcohol and refined grains, as
well as acid-forming foods such as red meat and coffee, and potentially
moldy food such as leftovers and dried fruits and nuts. Many people with
candida also cannot tolerate diary products. Instead the focus should be
placed on salads and lightly cooked alkaline vegetables, cold-pressed
oils, seaweed/algae, miso, and fresh fish (mercury/PCB free). Alkaline
substances can help restore the bodily pH balance (e.g., coral calcium,
green powder drinks, apple cider vinegar, umeboshi paste, etc.).
-Enzymes in
the mitochondria are governed by ions that in turn are controlled by
over 300 mineral salts that are present in organisms. A sufficient
supply is possible with base mineral salt mixtures (e.g. Nimbasit or the
sango coral sediment, Sancoral). Direct administration of enzymes
(Wobenzym) can be effected with intervals (7 capsules in one week
followed by a weeks gap).
- Parasites
(e.g. worms, flukes, etc.) are immunosuppressive; they cause
inflammatory tissue damage and can thereby inactivate NO synthesis via
inhibitory counterregulation. Various herbs are effective in expelling
parasites; the combination of wormwood, black walnut extract and freshly
ground cloves is a popular one. Also effective is papaya leaves: 20 per
day, for five days, ground and mixed with food or drink. Periodic
parasite cleansing, even if asymptomatic, is especially recommended for
sexually active gay men.
-The vast
majority of lymphatic tissue is in the gut mucosa, so it is prudent to
maintain healthy intestines for proper immune function. It is imperative
to repopulate the intestinal flora with probiotics after (and perhaps
during) the use of antibiotic and/or antifungal substances. FOS
(fructooligosaccharides) and lacto-fermented food and beverages (e.g.
kimchee, unpasteurized sauerkraut, beet kvass, Kanne bread drink, etc.),
work as pre-biotics and can help alleviate bacterial dysbiosis in the
intestines. N-acetyl-glucosamine, L-glutamine, and oils of rice bran,
olive, and sesame, can also help soothe and rebuild the gut lumen after
intestinal inflammation (e.g. diarrhea, parasites, candida, etc.).
- Mycosis,
skin and mouth infections, and internal infections can be treated with
grapefruit seed extract (GSE) or emulsions made of it, which are highly
effective against a multiplicity of fungi, viruses and both
gram-positive and gram-negative bacteria. For external use, creams
containing snake venom or sulphur, and also tea tree oil or acidophilus
have worked well in practice.
-
Coriander/cilantro extracts, Allium ursinum, Chlorella algae, Selen,
homeopathics, and EDTA chelation can assist in the binding and excretion
of toxic heavy metals. (Especially avoid vaccines given from
multiple-use bottles should be avoided, as they nearly always contain
toxic mercury compounds)
- Targeted
stress-reduction techniques, e.g. autogenic training, meditation, gentle
yoga, and massage, are helpful; as is refraining from excessive physical
exercise and the frequent use of performance-enhancing drugs, e.g.
sugar, coffee, alcohol, nicotine, marijuana, amphetamines, ecstasy,
cocaine, heroin, and poppers – all of which heighten the release of
stress hormones in the adrenal gland. The amino acid triptophan
(100-300mg daily) , is released in the small intestine (if administrated
in capsules resistant to gastric juice) is effective to heighten the
release of serotonin, the antidepressant substances in the body, that
can be lacking due to psychic stress or malnutrition.
- At anal
intercorse, condoms are recommended to avoid genuine venereal infections
and blood-plasma contact with seminal fluids, which place additional
oxidative burdens on the immune system. Avoid inflammatory injury to the
mucosal tissues (fisting, rough sex, etc.), and abstain from the use of
poppers, which are strongly immunosuppressive and can lead to swollen
lymph nodes and respiratory fungal infections (PCP). Also avoid the use
of highly-chemicalized lubricants that would not be safe to ingest by
mouth (Probe™ is a brand with minimally toxic ingredients).
- The intake
of blood-derived clotting factors, as well as blood transfusions should
be avoided in order to avoid further oxidative stress.
By the above
means, a flexible resistance and healthy constitution can be restored in
people with AIDS-defining illnesses.
If limited
administration of chemoantibiotics is necessary, it is most urgent that
the basic restorative therapy (revolving around cysteine/glutathione
supplementation) be followed in tandem, to counteract the oxidizing
effects. Any treatment should also be adapted to the individual and
their specific symptoms, in cooperation with their doctor. The following
tests can be used to measure progress in bolstering the immune system:
stress hormone profiles, the CD4/CD8 ratio, macrophage activation
(neopterin test) and cutaneous anergy*, and the glutathione level in
blood plasma and CD4 cells.
*(The DTH
test is unfortunately no longer available, as Sanofi-Mérieux-Pasteur has
blocked its production worldwide so as not to interfere with its profit
interests in the testing of the so-called HIV-vaccines. Cutaneous anergy
is a better indicator of risk for AIDS than any “HIV test”.)
This document
was produced by:
Study Group
AIDS therapy
c/o Felix A. de Fries
Eglistr. 7 CH-8004 Zürich, Switzerland
felix.defries@tele2.ch
in
cooperation with
Alive and
Well San Francisco
c/o David Lowenfels
www.aliveandwellsf.info
